Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Comparison of the efficacy of half ticagrelor loading doses and clopidogrel in elderly acute coronary syndrome patients in China

Jian Xue, Mingming Li, Lijie Wang, Minjun Ma, Jin Zhang

Department of Cardiology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China;

For correspondence:- Jin Zhang Email: Jin_Zhang_CA@yeah.net Tel:+8613331056690

Accepted: 26 February 2020 Published: 31 March 2020

Citation: Xue J, Li M, Wang L, Ma M, Zhang J. Comparison of the efficacy of half ticagrelor loading doses and clopidogrel in elderly acute coronary syndrome patients in China. Trop J Pharm Res 2020; 19(3):661-666 doi: 10.4314/tjpr.v19i3.29

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the effects of half-load doses (HLD) of ticagrelor and clopidogrel on elderly acute coronary syndrome patients (ACS) over a period of 90 days.

Methods: Seventy-four patients diagnosed as ACS were included in this trial. The patients were randomly distributed into group 1 (treated with HLD ticagrelor, 90 mg LD) and group 2 (treated with clopidogrel, 300 mg LD). The interaction of treatment effect was evaluated using Multivariate Cox proportional hazards regression models.

Results: Within three months, a total of 12 patients (16.21 %) died of myocardial infarction or stroke. The endpoint of HLD ticagrelor-treated elderly ACS patients was 20 %, and the incidence of clopidogrel-treated endpoints was 14.81 %.

Conclusion: In the first 45 patients treated with HLD ticagrelor, their cumulative incidence of cardiac events was relatively high. However, there were no considerable changes in the therapeutic benefits of these two drugs in elderly ACS patients.

Keywords: Elder patients, Acute coronary syndrome, Ticagrelor, Clopidogrel